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The fourth ventricle is one of the four connected fluid-filled cavities within the human brain. These cavities, known collectively as the ventricular system, consist of the left and right lateral ventricles, the third ventricle, and the fourth ventricle. The fourth ventricle extends from the cerebral aqueduct ( aqueduct of Sylvius) to the obex, and is filled with cerebrospinal fluid (CSF).
The fourth ventricle has a characteristic diamond shape in cross-sections of the human brain. It is located within the pons or in the upper part of the medulla oblongata. CSF entering the fourth ventricle through the cerebral aqueduct can exit to the subarachnoid space of the spinal cord through two lateral apertures and a single, midline median aperture.
The superior portion of the roof (i.e. of the posterior edge) is formed, in the midline, by a thin lamina called the superior medullary velum, and laterally by the cerebellar peduncles. The inferior portion of the roof is formed superiorly by the inferior medullary veli and the vermis of the Cerebellum (covered with choroid plexus), and inferiorly by the Tela choroidea. The inferior portion of the roof is where CSF can escape the ventricle through three openings: Near each of the three corners of the inferior roof there is an opening into the cisterna magna, the caudal opening being the median aperture, while the lateral openings are the Lateral aperture. Therefore, the fourth ventricle is the connector between the ventricular system (where CSF is produced) and the subarachnoid space (where CSF is absorbed). The roof rises (i.e. posteriorly) to a peak, known as the fastigium (Latin for "summit"); the fastigial nucleus lies immediately above the roof of the fourth ventricle, in the cerebellum.
The floor (i.e. the anterior edge) of the fourth ventricle constitutes the rhomboid fossa, and comprises a number of general features. A sulcus - the median sulcus - extends the length of the ventricle (from the cerebral aqueduct of the midbrain to the central canal of the spinal cord), dividing the floor into right and left halves. Each half is further divided by a further sulcus - the sulcus limitans - along a line parallel to the median sulcus; within the floor, motor neurons are located medially of the sulcus limitans, while sensory neurons are located laterally. The elevation between the median sulcus and sulcus limitans (i.e. the region for motor neurons), is known as the medial eminence, while the lateral region (i.e. that for the sensory neurons) is known as the vestibular area. The sulcus limitans bifurcates at either end - the superior fovea cerebrally, and the inferior fovea caudally.
The pons is located behind the middle and superior portion of the floor. In the superior region of the pons is the locus coeruleus, which due to its concentration of noradrenaline has a sky blue appearance, visible (in a colour closer to teal) through the floor of the ventricle, superiorly to the superior fovea. The internal part of the facial nerve bulges into the ventricle, forming the facial colliculus, in the process of looping around the abducens nucleus within the inferior region of the Pons.
The medulla oblongata is located behind the inferior portion of the floor (and continues caudally of the ventricle). Medullary striae emerge via the median sulcus and run transversely across the floor to become part of the inferior cerebellar peduncle. The hypoglossal nucleus bulges into the floor, creating the hypoglossal trigone, located slightly superiorly to the inferior fovea, within the median eminence. The dorsal nucleus of vagus nerve, within the medulla oblongata, comprises cells that are spindle shaped, also creating a bulge—the vagal trigone—in the region of the floor which overlies them; this is the region inferior of the inferior fovea.
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